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Endoscopy to look for blockages or problems in the upper digestive system

Semaglutide works by mimicking the effects of the hormone GLP-1, which plays a crucial role in controlling appetite, food intake, and blood sugar levels

The impact on specific food cravings is not uniform across all patients

One of the first studies that delivered GLP-1 into the brain was published in 1995, and showed that injection of intracerebroventricular (ICV) GLP-1 into hypothalamic regions reduced feeding and increased c-fos activity in the PVH and CeA [52]

Upon binding to GLP-1R, GLP-1 triggers the activation of the G protein, which stimulates adenylyl cyclase [4]